Abstract
It has been proposed that the acquisition of drug seeking is related to the development of conditioned dopamine responses in the ventral striatum. As drug use continues and becomes habit-like, conditioned responses have been shown to shift to the dorsal striatum. Here, using the PET [11C]raclopride method and highly personalized cocaine cues, we report the first evidence in humans of the dorsal dopamine response prior to the onset of addiction.
MeSH terms
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Adolescent
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Adult
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Behavior, Addictive / diagnostic imaging
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Carbon Radioisotopes / chemistry
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Cocaine / pharmacology*
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Cocaine-Related Disorders / diagnostic imaging
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Corpus Striatum / diagnostic imaging
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Corpus Striatum / drug effects*
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Corpus Striatum / metabolism
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Cues
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Dopamine / metabolism*
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Dopamine Uptake Inhibitors / pharmacology
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Drug-Seeking Behavior / drug effects*
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Humans
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Male
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Positron-Emission Tomography / methods
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Raclopride / chemistry
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Surveys and Questionnaires
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Young Adult
Substances
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Carbon Radioisotopes
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Dopamine Uptake Inhibitors
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Raclopride
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Cocaine
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Dopamine