Abstract
An analysis of the segregation of restriction fragment length polymorphisms in an Old Order Amish pedigree has made it possible to localize a dominant gene conferring a strong predisposition to manic depressive disease to the tip of the short arm of chromosome 11.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adolescent
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Adult
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Bipolar Disorder / epidemiology
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Bipolar Disorder / ethnology
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Bipolar Disorder / genetics*
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Christianity
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Chromosomes, Human, Pair 11*
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DNA / genetics
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Ethnicity
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Genetic Markers*
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Humans
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Pedigree
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Pennsylvania
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Polymorphism, Restriction Fragment Length
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Religion and Medicine