Abstract
Neurotensin receptor autoradiography reveals dense binding in normal human substantia nigra. In nigra from patients with Parkinson's disease, nigral receptor binding is only about one-third of control values. 'Saturation' analysis suggests that these changes result from receptor loss. These results support a neurotensin-dopamine interaction in human nigro-striatal circuits.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Age Factors
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Aged
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Autoradiography
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Humans
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Kinetics
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Middle Aged
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Neurotensin / metabolism*
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Parkinson Disease / metabolism*
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Receptors, Neurotensin
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Receptors, Neurotransmitter / metabolism*
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Reference Values
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Substantia Nigra / metabolism*
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Tritium
Substances
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Receptors, Neurotensin
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Receptors, Neurotransmitter
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Tritium
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Neurotensin