Abstract
While inducing similar progesterone levels, the ratio of 5 alpha- and 5 beta-pregnanolone/progesterone plasma concentrations has been dramatically increased after oral as opposed to vaginal administration, in a cross-over study. The known psychotropic effects of 5 alpha- and 5 beta-pregnanolone lead to different indications and precautions for oral and vaginal administration of progesterone.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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20-alpha-Dihydroprogesterone / blood
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Administration, Intravaginal
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Administration, Oral
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Cross-Over Studies
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Desoxycorticosterone / blood
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Female
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Humans
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Pregnanolone / blood
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Progesterone / administration & dosage*
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Progesterone / blood
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Progesterone / pharmacokinetics*
Substances
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20-alpha-Dihydroprogesterone
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Desoxycorticosterone
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Progesterone
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Pregnanolone