Abstract
The effects of the selective CCK-B agonists, BC 264 and BC 197, and the nonselective CCK agonist BDNL were investigated in the elevated plus-maze in rats. BDNL and BC 197 induced anxiogeniclike effects, in contrast to BC 264, which had no effect. The behavioral responses induced by BDNL were not significantly blocked by L-365,260, but were suppressed by CI-988, another selective CCK-B antagonist, and by high doses of L-364,718, a selective CCK-A antagonist. BC 197-induced effects were also blocked by CI-988. Competition experiments performed with [3H]pBC 264 using brain membranes of guinea pig, mouse, and rat were significantly better fitted when analyzed by a two site model than by a one site model with BC 197 but not with BC 264. Moreover, BC 264 produced anxiogeniclike effects when administered with increasing doses of L-365,260 and opposing effects with increasing doses of CI-988. Together these results give pharmacological and behavioral evidence for the existence of CCK-B receptor subtypes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Anxiety / metabolism*
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Anxiety / psychology
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Behavior, Animal / drug effects
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Benzodiazepinones / pharmacokinetics
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Benzodiazepinones / pharmacology
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Cholecystokinin / analogs & derivatives
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Cholecystokinin / pharmacokinetics
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Cholecystokinin / pharmacology
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Devazepide
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Guinea Pigs
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In Vitro Techniques
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Indoles / pharmacokinetics
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Indoles / pharmacology
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Male
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Meglumine / analogs & derivatives
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Meglumine / pharmacokinetics
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Meglumine / pharmacology
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Mice
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Molecular Sequence Data
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Pancreas / drug effects
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Pancreas / metabolism
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Peptide Fragments / pharmacokinetics
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Peptide Fragments / pharmacology
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Phenylurea Compounds*
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Rats
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Rats, Sprague-Dawley
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Rats, Wistar
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Receptors, Cholecystokinin / agonists
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Receptors, Cholecystokinin / antagonists & inhibitors
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Receptors, Cholecystokinin / metabolism*
Substances
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BC 264
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Benzodiazepinones
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Indoles
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Peptide Fragments
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Phenylurea Compounds
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Receptors, Cholecystokinin
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BC 197
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PD 134308
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L 365260
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Meglumine
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Cholecystokinin
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Devazepide