Abstract
Naltrindole, a specific delta-opioid antagonist, infused by reverse dialysis in the nucleus accumbens of freely moving rats completely prevented the increase in extracellular dopamine concentrations elicited in the nucleus accumbens by ethanol (1.0 g/kg i.p.) as well as by the delta-opioid receptor agonist [D-Ala2]deltorphin II (50 microM), also perfused by reverse dialysis, but not by cocaine (15 mg/kg s.c.). The results provide in vivo evidence for a critical role of delta-opioid receptors in the dopamine-releasing properties of ethanol in vivo.
MeSH terms
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Animals
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Cocaine / pharmacology
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Dopamine / metabolism*
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Ethanol / antagonists & inhibitors*
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Indoles / pharmacology*
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Male
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Morphinans / pharmacology*
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Naltrexone* / analogs & derivatives*
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Narcotic Antagonists / pharmacology*
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Nucleus Accumbens / drug effects*
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Nucleus Accumbens / metabolism
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Oligopeptides / pharmacology
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Rats
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Rats, Sprague-Dawley
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Receptors, Opioid, delta / antagonists & inhibitors*
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Receptors, Opioid, delta / physiology
Substances
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Indoles
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Morphinans
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Narcotic Antagonists
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Oligopeptides
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Receptors, Opioid, delta
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deltorphin II, Ala(2)-
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Ethanol
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Naltrexone
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naltrindole
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Cocaine
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Dopamine