Abstract
The authors administered 48 mg of intravenous cocaine or placebo to eight abstinent cocaine users in a double-blind, crossover design and examined blood flow using single photon emission computed tomography. Cocaine produced significant decreases in frontal cortical and basal ganglia blood flow; these latter correlated negatively with increases in self-ratings of "rush" and "high." The authors conclude that these local effects are compatible with dopaminergic system involvement.
Publication types
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Clinical Trial
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Controlled Clinical Trial
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Affect / drug effects*
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Basal Ganglia / blood supply
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Basal Ganglia / drug effects
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Cerebrovascular Circulation / drug effects*
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Cocaine / pharmacology*
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Double-Blind Method
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Frontal Lobe / blood supply
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Frontal Lobe / drug effects
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Humans
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Male
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Receptors, Dopamine / drug effects
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Receptors, Dopamine / physiology
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Substance-Related Disorders / physiopathology
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Substance-Related Disorders / psychology*
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Tomography, Emission-Computed, Single-Photon
Substances
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Receptors, Dopamine
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Cocaine