Abstract
The levels of 5-hydroxytryptamine have been measured in 33 areas of the human brain and these levels compared in depressed suicides, in alcoholic suicides, and in controls. The values obtained for control brains ranged from 5.3 mumole 5-HT/kg wet weight in substantia nigra to 0.4 mumole 5-HT/kg wet weight in frontal gray. No significant differences were found among diagnostic groups in any of the areas studied.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adult
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Aged
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Alcoholism / metabolism*
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Amygdala / metabolism
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Animals
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Brain / metabolism*
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Brain Chemistry
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Caudate Nucleus / metabolism
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Cerebellum / metabolism
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Cerebral Cortex / metabolism
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Depression / metabolism*
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Female
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Globus Pallidus / metabolism
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Gyrus Cinguli / metabolism
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Hippocampus / metabolism
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Humans
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Hypothalamus / metabolism
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Male
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Middle Aged
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Pons / metabolism
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Putamen / metabolism
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Rats
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Serotonin / metabolism*
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Substantia Nigra / metabolism
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Suicide*
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Tectum Mesencephali / metabolism
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Tegmentum Mesencephali / metabolism
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Thalamus / metabolism