Abstract
Amphetamine produces locomotor stereotypy (repetitive routes of locomotion) in an open field. In this research we tested the ability of the D1 antagonist SKF 83566 and the D2 antagonist sulpiride to block the locomotor stereotypy produced by 2 mg/kg amphetamine. SKF 83566 decreased amphetamine-induced locomotor stereotypy; sulpiride had no consistent effect on amphetamine-induced locomotor stereotypy. There was no evidence that either antagonist potentiated the effect of the other.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / analogs & derivatives
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / therapeutic use
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Amphetamine / antagonists & inhibitors*
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Amphetamine / toxicity*
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Animals
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Dopamine Antagonists / therapeutic use*
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Dopamine D2 Receptor Antagonists*
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Dopamine Uptake Inhibitors / antagonists & inhibitors*
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Dopamine Uptake Inhibitors / toxicity*
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Drug Interactions
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Male
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Rats
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Rats, Wistar
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Receptors, Dopamine D1 / antagonists & inhibitors*
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Stereotyped Behavior / drug effects*
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Sulpiride / therapeutic use
Substances
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Dopamine Antagonists
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Dopamine D2 Receptor Antagonists
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Dopamine Uptake Inhibitors
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Receptors, Dopamine D1
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2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
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Sulpiride
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Amphetamine
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1H-3-benzazepin-7-ol, 8-bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-