Abstract
In clinical practice, patients are encountered who are partial responders or nonresponders to clozapine. There are others who are unable to tolerate a high dosage of clozapine. In the two cases presented, we propose an alternative strategy using olanzapine in combination with clozapine in treatment-refractory patients. Olanzapine was found to be helpful in these patients, however, controlled studies are needed.
MeSH terms
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Adult
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Antipsychotic Agents / administration & dosage*
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Antipsychotic Agents / pharmacology
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Benzodiazepines
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Clozapine / administration & dosage*
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Clozapine / pharmacology
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Drug Interactions
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Drug Resistance
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Drug Therapy, Combination
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Female
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Humans
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Male
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Middle Aged
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Olanzapine
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Pirenzepine / administration & dosage
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Pirenzepine / analogs & derivatives*
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Pirenzepine / pharmacology
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Schizophrenia / drug therapy*
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Treatment Outcome
Substances
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Antipsychotic Agents
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Benzodiazepines
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Pirenzepine
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Clozapine
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Olanzapine