User profiles for Alex D. Shaw

Alexander D Shaw

University of Exeter
Verified email at exeter.ac.uk
Cited by 749

CYLD is a causative gene for frontotemporal dementia – amyotrophic lateral sclerosis

…, PK Panegyres, J Hecker, G Nicholson, AD Shaw… - Brain, 2020 - academic.oup.com
Frontotemporal dementia and amyotrophic lateral sclerosis are clinically and pathologically
overlapping disorders with shared genetic causes. We previously identified a disease locus …

An examination of multiple classes of rare variants in extended families with bipolar disorder

C Toma, AD Shaw, RJN Allcock, A Heath… - Translational …, 2018 - nature.com
Bipolar disorder (BD) is a complex psychiatric condition with high heritability, the genetic
architecture of which likely comprises both common variants of small effect and rare variants of …

Traumatic stress interacts with bipolar disorder genetic risk to increase risk for suicide attempts

…, C Brucksch, A Frankland, C Toma, AD Shaw… - Journal of the American …, 2017 - Elsevier
Objective Bipolar disorder (BD) is one of the most heritable psychiatric conditions and is
associated with high suicide risk. To explore the reasons for this link, this study examined the …

Model updating strategy for structures with localised nonlinearities using frequency response measurements

X Wang, TL Hill, SA Neild, AD Shaw… - … Systems and Signal …, 2018 - Elsevier
This paper proposes a model updating strategy for localised nonlinear structures. It utilises
an initial finite-element (FE) model of the structure and primary harmonic response data taken …

Comprehensive cross-disorder analyses of CNTNAP2 suggest it is unlikely to be a primary risk gene for psychiatric disorders

C Toma, KD Pierce, AD Shaw, A Heath… - PLoS …, 2018 - journals.plos.org
The contactin-associated protein-like 2 (CNTNAP2) gene is a member of the neurexin
superfamily. CNTNAP2 was first implicated in the cortical dysplasia-focal epilepsy (CDFE) …

Oscillatory, computational, and behavioral evidence for impaired GABAergic inhibition in schizophrenia

AD Shaw, L Knight, TCA Freeman… - Schizophrenia …, 2020 - academic.oup.com
The dysconnection hypothesis of schizophrenia (SZ) proposes that psychosis is best
understood in terms of aberrant connectivity. Specifically, it suggests that dysconnectivity arises …

GABAergic cortical network physiology in frontotemporal lobar degeneration

…, LE Hughes, MA Rouse, HN Phillips, AD Shaw… - Brain, 2021 - academic.oup.com
The clinical syndromes caused by frontotemporal lobar degeneration are heterogeneous,
including the behavioural variant frontotemporal dementia (bvFTD) and progressive …

Truncating variant burden in high-functioning autism and pleiotropic effects of LRP1 across psychiatric phenotypes

B Torrico, AD Shaw, R Mosca, N Vivó-Luque… - Journal of Psychiatry and …, 2019 - jpn.ca
Background: Previous research has implicated de novo and inherited truncating mutations
in autism-spectrum disorder. We aim to investigate whether the load of inherited truncating …

Peak visual gamma frequency is modified across the healthy menstrual cycle

RL Sumner, RL McMillan, AD Shaw… - Human brain …, 2018 - Wiley Online Library
Fluctuations in gonadal hormones over the course of the menstrual cycle are known to cause
functional brain changes and are thought to modulate changes in the balance of cortical …

Twist morphing of a composite rotor blade using a novel metamaterial

H Gu, AD Shaw, M Amoozgar, J Zhang, C Wang… - Composite structures, 2020 - Elsevier
A novel meta-material has been designed and implemented into a rotor blade to enhance
aerodynamic efficiency by achieving a passive twist during rotation. The twist is induced by …