OBJECTIVES: The aim of the study is to map a neural network of emotion processing and to
identify differences in major depression compared to healthy controls. It is hypothesized that …

Objective. The interplay of genetic and early environmental factors is recognized as an important
factor in the aetiology of major depressive disorder (MDD). The aim of the present study …

Alterations in white matter (WM) microstructure have been implicated in the pathophysiology
of major depressive disorder (MDD). However, previous findings have been inconsistent, …

The interaction between adverse life events during childhood and genetic factors is
associated with a higher risk to develop major depressive disorder (MDD). One of the …

Major depressive disorder (MDD) is associated with an increased risk of brain atrophy,
aging-related diseases, and mortality. We examined potential advanced brain aging in adult …

Serotonin plays an important role in the etiology of depression. Serotonin is also crucial for
brain development. For instance, animal studies have demonstrated that early disruptions in …

Background: Childhood maltreatment has been found to play a crucial role in the development
of psychiatric disorders. However, whether childhood maltreatment is associated with …

Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here
we aimed to clarify the relationship between obesity and brain structure using structural MRI (…

The kynurenine pathway (KP) and its rate-limiting tryptophan degrading enzyme indolamine
2,3-dioxygenase (IDO) have been implicated in the pathogenesis of depression. IDO …

Childhood adversity plays an important role for development of major depressive disorder (MDD).
There are differences in subcortical brain structures between patients with MDD and …