OBJECTIVES:: To perform a systematic review comparing the diagnostic accuracy of CysC
with SCr. METHODS:: MEDLINE and EMBASE (January 1984–February 2006) were …

Nutrapharmacology, or the use of bioactive food compounds at pharmacological doses is
emerging as a therapeutic approach to target the complex metabolic dysregulations in ageing …

Background: A variety of body size covariates have been used in population pharmacokinetic
analyses to describe variability in drug clearance (CL), such as total body weight (TBW), …

Objectives To compare the plasma and subcutaneous tissue concentration–time profiles of
meropenem administered by intermittent bolus dosing or continuous infusion to critically ill …

Background & Aims Nonalcoholic fatty liver disease (NAFLD), characterized by accumulation
of hepatic triglycerides (steatosis), is associated with abdominal obesity, insulin resistance, …

The objectives of this study were (i) to compare the plasma concentration–time profiles for
first-dose and steady-state piperacillin administered by intermittent or continuous dosing to …

… Kirkpatrick, a senior fel low with the American Asso ciation of … Kirkpatrick brings to EMU
an impressive academic and … Having a strong back ground in academics, Kirkpatrick has …

Infections in critically ill patients continue to result in unacceptably high morbidity and mortality.
Although few data exist for correlating antibiotic exposure with outcome, antibiotic dosing …

Introduction The aim of this study was to explore the impact of augmented creatinine clearance
and differing minimum inhibitory concentrations (MIC) on piperacillin pharmacokinetic/…

Aims To review the basis and optimal use of therapeutic drug monitoring of antimicrobial
agents. Methods Antimicrobial agents for which a reasonable case exists for therapeutic drug …