Objectif: Seule une minorité d’utilisateurs de drogues et d’alcool développe un trouble d’utilisation
de substances. Les études précédentes suggèrent que cette vulnérabilité …

Background Most studies investigating the neurobiology of depression and suicide have
focused on the serotonergic system. While it seems clear that serotonergic alterations play a …

OBJECTIVE: Major depression is a major risk factor for suicide. However, not all individuals
with major depression commit suicide. Impulsive and aggressive behaviors have been …

Microdialysis experiments in rodents indicate that ethanol promotes dopamine release
predominantly in the nucleus accumbens, a phenomenon that is implicated in the reinforcing …

Eight healthy men underwent two positron emission tomography (PET) [ 11 C]raclopride
scans, one following placebo, the second following d-amphetamine (0.30 mg/kg, po). PET data …

• In a recent study, we reported abnormal local cerebral glucose metabolic rates in the
orbital frontal cortex of patients with obsessive-compulsive disorder. Eight patients with …

Context In animals, repeated exposure to stimulant drugs leads to an enhanced drug-induced
psychomotor response and increased dopamine release. This phenomenon, known as …

Despite a relatively large body of literature on the role of the neurotransmitter serotonin (5-hydroxytryptamine,
or 5-HT) in the regulation of alcohol intake, the functional significance of …

Methods: A double-blind placebo-controlled cross-over study in which plasma tryptophan was
manipulated by administration of a tryptophan-deficient amino acid mixture. In the placebo …

Brain metabolism was measured with positron emission tomography and [18F] 2-fluoro-2-deoxyglucose
in normal subjects and in patients with obsessive compulsive disorder (OCD) …