Huntington's disease is a neurodegenerative disorder caused by CAG expansion that results
in expansion of a polyglutamine tract at the extreme N terminus of huntingtin (htt). htt with …

Huntington's disease (HD) results from polyglutamine expansion in huntingtin (htt), a protein
with several consensus caspase cleavage sites. Despite the identification of htt fragments in …

The neurodegenerative diseases Huntington disease, dentatorubropallidoluysian atrophy,
spinocerebellar atrophy type 3, and spinal bulbar muscular atrophy are caused by expansion …

Mutations in ABCA1 cause the allelic disorders familial hypolipoproteinemia and Tangier
Disease. To identify where ABCA1 was likely to have a functional role, we determined the …

ABCA1 is a cholesterol transporter that is widely expressed throughout the body. Outside
the central nervous system (CNS), ABCA1 functions in the biogenesis of high-density …

Cleavage of huntingtin (htt) has been characterized in vitro, and accumulation of caspase
cleavage fragments represents an early pathological change in brains of Huntington's disease …

Previous work suggests N-methyl-D-aspartate receptor (NMDAR) activation may be involved
in degeneration of medium-sized spiny striatal neurons in Huntington's disease (HD). Here …

Huntington's disease (HD) is caused by polyglutamine expansion (exp) in huntingtin (Htt). The
type 1 inositol (1,4,5)-triphosphate receptor (InsP 3 R1) is an intracellular calcium (Ca 2+ ) …

Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous
disease with multiple contributors to its pathophysiology, including vascular dysfunction…

APOE genotype is a major genetic risk factor for late-onset Alzheimer disease (AD). ABCA1,
a member of the ATP-binding cassette family of active transporters, lipidates apoE in the …