Myocarditis remains a clinical challenge in pediatrics. Originally, it was recognized at
autopsy before the application of endomyocardial biopsy, which led to a histopathology-based …

IL6 is a pleiotropic cytokine that is made in response to perturbations in homeostasis. IL6
becomes elevated in the acute response to host injury and can activate immune cells, direct …

Rationale: One-third of myocarditis cases progresses to dilated cardiomyopathy (DCM), but
the mechanisms controlling this process are largely unknown. CD4 + T helper (Th)17 cells …

Myocarditis is the inflammation of the muscle tissues of the heart (myocardium). After a
pathologic cardiac-specific inflammatory process, it may progress to chronic damage and dilated …

Inflammatory dilated cardiomyopathy (DCMi) is a major cause of heart failure in individuals
below the age of 40. We recently reported that IL-17A is required for the development of DCMi…

Eosinophils are multifunctional granulocytes that contribute to initiation and modulation of
inflammation. Their role in asthma and parasitic infections has long been recognized. Growing …

Expression of the intermediate filament protein keratin 17 (K17) is robustly upregulated in
inflammatory skin diseases and in many tumors originating in stratified and pseudostratified …

Medical devices and implants made of synthetic materials can induce an immune-mediated
process when implanted in the body called the foreign body response, which results in …

Background Thromboembolism is a life-threatening manifestation of coronavirus disease
2019 (COVID-19). We investigated a dysfunctional phenotype of vascular endothelial cells in …

This chapter describes four murine models of autoimmune diseases: two related to autoimmune
myocarditis and two related to autoimmune thyroiditis. The first model, Coxsackie virus …