Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin
…, MM Sánchez, KC Mathys, K Ebner, E Frank… - …, 2004 - nature.com
To model aspects of trait anxiety/depression, Wistar rats were bred for extremes in either
hyper (HAB)-or hypo (LAB)-anxiety as measured on the elevated plus-maze and in a variety of …
hyper (HAB)-or hypo (LAB)-anxiety as measured on the elevated plus-maze and in a variety of …
Negativity towards negative results: a discussion of the disconnect between scientific worth and scientific culture
Science is often romanticised as a flawless system of knowledge building, where scientists
work together to systematically find answers. In reality, this is not always the case. …
work together to systematically find answers. In reality, this is not always the case. …
The vasopressin system—from antidiuresis to psychopathology
E Frank, R Landgraf - European journal of pharmacology, 2008 - Elsevier
Vasopressin is a neuropeptide with multiple functions. In addition to its predominantly antidiuretic
action after peripheral secretion from the posterior pituitary, it seems to fulfill – together …
action after peripheral secretion from the posterior pituitary, it seems to fulfill – together …
Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: focus on vasopressin and glyoxalase-I
…, CW Turck, N Singewald, D Rujescu, E Frank - Neuroscience & …, 2007 - Elsevier
Two animal models of trait anxiety, HAB/LAB rats and mice, are described, representing inborn
extremes in anxiety-related behavior. The comprehensive phenotypical characterization …
extremes in anxiety-related behavior. The comprehensive phenotypical characterization …
Viral vector‐mediated gene transfer of the vole V1a vasopressin receptor in the rat septum: improved social discrimination and active social behaviour
R Landgraf, E Frank, JM Aldag… - European Journal of …, 2003 - Wiley Online Library
This study explores the effects of enhancing vasopressin V1a receptor expression in the
septum using viral vector‐mediated gene transfer on social discrimination and social …
septum using viral vector‐mediated gene transfer on social discrimination and social …
Effects of deliberative and implemental mindsets on persistence in goal-directed behavior
V Brandstätter, E Frank - Personality and Social Psychology …, 2002 - journals.sagepub.com
In three experiments with a total of 243 students, the hypothesis was tested that mindsets
affect goal-directed persistence in behavioral conflict situations. In Studies 1 and 2, an …
affect goal-directed persistence in behavioral conflict situations. In Studies 1 and 2, an …
Proteomics and metabolomics analysis of a trait anxiety mouse model reveals divergent mitochondrial pathways
…, S Reckow, P Gormanns, G Maccarrone, E Frank… - Biological …, 2011 - Elsevier
BACKGROUND: Although anxiety disorders are the most prevalent psychiatric disorders, no
molecular biomarkers exist for their premorbid diagnosis, accurate patient subcategorization…
molecular biomarkers exist for their premorbid diagnosis, accurate patient subcategorization…
Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety
C Murgatroyd, A Wigger, E Frank… - Journal of …, 2004 - Soc Neuroscience
Two inbred rat lines have been developed that show either high (HAB) or low (LAB) anxiety-related
behavior. The behavioral phenotype correlates with arginine vasopressin (AVP) …
behavior. The behavioral phenotype correlates with arginine vasopressin (AVP) …
Impaired extinction of learned fear in rats selectively bred for high anxiety–evidence of altered neuronal processing in prefrontal‐amygdala pathways
…, M Hauschild, S Gaburro, E Frank… - European Journal of …, 2008 - Wiley Online Library
The impaired extinction of acquired fear is a core symptom of anxiety disorders, such as post‐traumatic
stress disorder, phobias or panic disorder, and is known to be particularly …
stress disorder, phobias or panic disorder, and is known to be particularly …
Genetic predisposition to anxiety-related behavior determines coping style, neuroendocrine responses, and neuronal activation during social defeat.
E Frank, P Salchner, JM Aldag, N Salomé… - Behavioral …, 2006 - psycnet.apa.org
Genetic background may influence an individual's susceptibility to, and subsequent coping
strategy for, an acute stressor. When exposed to social defeat (SD), rats bred for high (HAB) …
strategy for, an acute stressor. When exposed to social defeat (SD), rats bred for high (HAB) …