Context In animals, repeated exposure to stimulant drugs leads to an enhanced drug-induced
psychomotor response and increased dopamine release. This phenomenon, known as …

Alzheimer disease is the most prevalent form of dementia globally and is characterized
premortem by a gradual memory loss and deterioration of higher cognitive functions and …

A continuous, peroxidase-linked spectrophotometric assay is described which is suitable for
measuring monoamine and diamine oxidase and semicarbazide-sensitive amine oxidase …

Risperidone is a relatively new antipsychotic drug that has been reported to improve both
the positive and the negative symptoms of schizophrenia and produces relatively few …

Disposable plasticware such as test tubes, pipette tips, and multiwell assay or culture plates
are used routinely in most biological research laboratories. Manufacturing of plastics …

Awareness of the metabolism of second-generation antipsychotics by the cytochrome P450 (CYP)
system can inform the clinician about how to avoid and manage drug–drug …

High-throughput technologies have led to advances in the recognition of disease pathways
and their underlying mechanisms. To investigate the impact of micro-RNAs on the disease …

Ketamine, a drug introduced in the 1960s as an anesthetic agent and still used for that
purpose, has garnered marked interest over the past two decades as an emerging treatment for …

Schizophrenia is a heterogeneous psychiatric disorder that is poorly treated with current
therapies. In this brief review, we provide an update regarding the use of animal models to study …

Abnormal N -methyl- d -aspartate receptor (NMDAR) function has been implicated in the
pathophysiology of schizophrenia. d -serine is an important NMDAR modulator, and to …