Background: Obsessive–compulsive disorder (OCD) is a common psychiatric disorder that
affects about 2% of the population, but the underlying neuropathophysiology of OCD is not …

Background Synapse-associated protein 90/postsynaptic density protein 95-associated
protein 3 (SAPAP3) is an excitatory postsynaptic protein implicated in the pathogenesis of …

Obsessive-compulsive disorder (OCD) is a circuit disorder involving corticostriatal
projections, which play a role in motor control. The Sapap3-knockout (KO) mouse is a …

Obsessive-compulsive disorder (OCD) is a leading cause of illness-related disability, but the
neural mechanisms underlying OCD symptoms are unclear. One potential mechanism of …

Convergent functional neuroimaging findings implicate hyperactivity across the prefrontal
cortex (PFC) and striatum in the neuropathology of obsessive compulsive disorder (OCD) …

Hyperactivity in striatum is associated with compulsive behaviors in obsessive-compulsive
disorder (OCD) and related illnesses, but it is unclear whether this hyperactivity is due to …

Deletion of the obsessive-compulsive disorder (OCD)-associated gene SAP90/PSD-95-
associated protein 3 (Sapap3), which encodes a postsynaptic anchoring protein at …

Background Development of treatments for obsessive-compulsive disorder (OCD) is
hampered by a lack of mechanistic understanding about this prevalent neuropsychiatric …

In this issue of Biological Psychiatry, Monteiro and Feng (1) review recent studies using
animal models to investigate the neural mechanisms underlying obsessive-compulsive …

Obsessive compulsive disorder (OCD) is associated with disruption of sensorimotor gating,
which may contribute to difficulties inhibiting intrusive thoughts and compulsive rituals …