The mammalian Target of Rapamycin (mTOR) protein is a serine-threonine kinase that
regulates cell-cycle progression and growth by sensing changes in energy status. We …

FTO is a nuclear protein belonging to the AlkB-related non-haem iron- and 2-oxoglutarate-dependent
dioxygenase family. Although polymorphisms within the first intron of the FTO gene …

Leptin regulates food intake in adult mammals by stimulating hypothalamic anorexigenic
pathways and inhibiting orexigenic ones. In developing rodents, fat stores are low, yet …

Optimal early development in most species is dependent upon a stable relationship between
the mother and her infant. The research described here focuses on the reciprocal nature of …

OBJECTIVE Single nucleotide polymorphisms (SNPs) in intron 1 of fat mass– and obesity-associated
gene (FTO) are strongly associated with human adiposity, whereas Fto −/− mice …

Oleoylethanolamide (OEA), a lipid synthesized in the intestine, reduces food intake and
stimulates lipolysis through peroxisome proliferator-activated receptor-α. OEA also activates …

Individual cells must carefully regulate their energy flux to ensure nutrient levels are adequate
to maintain normal cellular activity. The same principle holds in multicellular organisms. …

WKHA rats constitute a recombinant inbred rat strain derived by phenotypic selection of the
progeny of hybrid F2 crosses between SHR and WKY rats. WKHA are normotensive and …

Leptin modifies the activity of the hypothalamic-pituitary-adrenal axis in adult rodents and
inhibits the production of glucocorticoids from human and rat adrenals in vitro. During …

Background: Alcohol is a caloric compound that can contribute to energy intake. Therefore,
peptides that regulate energy balance likely modify the motivation to consume alcohol. …