Ever increasing use of engineered carbon nanoparticles in nanopharmacology for selective
imaging, sensor or drug delivery systems has increased the potential for blood platelet–…

The inhibition of platelet adhesion by nitric oxide (NO) and prostacyclin and their mechanism
of action was studied. Platelet adhesion to collagen fibrils and endothelial cell matrix was …

Blood platelets limit blood loss at sites of vascular injury by forming a mechanical plug. They
are also involved in thrombosis, atherosclerosis, inflammation and metastasis. Platelet …

The vascular endothelium is now widely recognized as an organ with a variety of functions
important in the regulation of blood vessel tone and permeability, the coagulation of blood, …

The interactions between nanosized particles and living systems are commonly mediated
by what adsorbs to the nanoparticle in the biological environment, its biomolecular corona, …

The effect of S-nitroso-glutathione (GSNO), a stable nitrosothiol, on platelet activation was
examined in vitro and in vivo. 2. The adhesion of human platelets to fibrillar collagen and …

Background—Matrix metalloproteinases (MMPs) contribute to collagen degradation and
remodeling of the extracellular matrix after myocardial infarction; however, their role in …

The L-arginine:nitric oxide (NO) pathway is believed to exert many of its physiological
effects via stimulation of the soluble guanylyl cyclase (SGC); however, the lack of a selective …

Matrix metalloproteinase-2 (MMP-2, gelatinase A) and its tissue inhibitor (TIMP-2) are
mainly known for their roles in the (patho)physiological remodeling of the vasculature, …

In a report from 2008, The International Agency for Research on Cancer predicted a tripled
cancer incidence from 1975, projecting a possible 13-17 million cancer deaths worldwide by …