Increased levels of prostanoids have been implicated in various neuropathological diseases,
although little is known about their cellular sources inside the brain. In this study, we …

Recent studies indicated that the formation of a major constituent of Alzheimer's disease (AD)
senile plaques, called βA4‐peptide, does not result from normal processing of its precursor…

Objective: The authors’ goal was to test the hypothesis that the antidepressant effect of total
sleep deprivation can be maintained by initially avoiding sleep during a supposedly “critical” …

Primary insomnia is defined as difficulties in falling asleep, maintaining sleep or non-restorative
sleep accompanied by significantly impaired daytime functioning in the absence of a …

Disturbances of sleep are typical for most depressed patients and belong to the core
symptoms of the disorder. Polysomnographic sleep research has demonstrated that besides …

The concentration of cytokines such as Interleukin-6 (IL-6) has been reported to be elevated
in depressed and schizophrenic patients and, in healthy persons, upon stress. Interleukin-6 …

The Committee on Chronotherapeutics was recently formed by the International Society for
Affective Disorders (ISAD), which has asked us to provide a consensus review of …

The illicit recreational drugs cocaine, ecstasy and marijuana have pronounced effects upon
sleep. Administration of cocaine increases wakefulness and suppresses REM sleep. Acute …

Background We investigated whether the combination of multimodal behaviour therapy (BT)
with fluvoxamine is superior to BTand placebo in the acute treatment of severely ill in-…

We investigated the regulation of COX‐2 expression and activity by adenosine receptors in
rat microglial cells. The selective adenosine A 2a ‐receptor agonist CGS21680 and the non‐…