Reduced fecundity, associated with severe mental disorders 1 , places negative selection
pressure on risk alleles and may explain, in part, why common variants have not been found …

Schizophrenia is a complex disorder, caused by both genetic and environmental factors and
their interactions. Research on pathogenesis has traditionally focused on neurotransmitter …

Background Cannabis use is associated with increased risk of later psychotic disorder but
whether it affects incidence of the disorder remains unclear. We aimed to identify patterns of …

BackgroundThere is little consistency in how severe mental illness (SMI) is defined in practice,
and no operational definitions.AimsTo test two operationalised definitions, based on the …

Importance The value of early intervention in psychosis and allocation of public resources
has long been debated because outcomes in people with schizophrenia spectrum disorders …

Objective To determine burn-out levels and associated factors among healthcare personnel
working in a tertiary hospital of a highly burdened area of north-east Italy during the COVID-…

Deletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have
also been reported in two families with schizophrenia. We examined NRXN1, and the …

AimsHealthcare workers exposed to coronavirus 2019 (COVID-19) patients could be
psychologically distressed. This study aims to assess the magnitude of psychological distress and …

Background Similar to other health care sectors, mental health has moved towards the
secondary prevention, with the effort to detect and treat mental disorders as early as possible. …

Deletions and reciprocal duplications of the chromosome 16p13. 1 region have recently been
reported in several cases of autism and mental retardation (MR). As genomic copy number …