Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and …
Background: Metabotropic glutamate receptors 2/3 (mGluR2/3) and 5 (mGluR5) are novel
therapeutic targets for major depression (MD), bipolar disorder (BD) and schizophrenia. We …
therapeutic targets for major depression (MD), bipolar disorder (BD) and schizophrenia. We …
Differences in quantification of the metabotropic glutamate receptor 5 across bipolar disorder and major depressive disorder
Background Understanding the neurobiology underlying bipolar disorder (BD) versus major
depressive disorder (MDD) is crucial for accurate diagnosis and for driving the discovery of …
depressive disorder (MDD) is crucial for accurate diagnosis and for driving the discovery of …
[HTML][HTML] Rethinking metabotropic glutamate receptor 5 pathological findings in psychiatric disorders: implications for the future of novel therapeutics
Background Pharmacological modulation of metabotropic glutamate receptor 5 (mGluR5) is
of marked interest as a novel therapeutic mechanism to treat schizophrenia and major …
of marked interest as a novel therapeutic mechanism to treat schizophrenia and major …
Reduced Metabotropic Glutamate Receptor 5 Density in Major Depression Determined by [11C]ABP688 PET and Postmortem Study
A Deschwanden, B Karolewicz… - American Journal of …, 2011 - Am Psychiatric Assoc
Objective: Clinical and preclinical evidence suggests a hyperactive glutamatergic system in
clinical depression. Recently, the metabotropic glutamate receptor 5 (mGluR5) has been …
clinical depression. Recently, the metabotropic glutamate receptor 5 (mGluR5) has been …
Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression
AM Feyissa, WL Woolverton, JJ Miguel-Hidalgo… - Progress in Neuro …, 2010 - Elsevier
Clinical, postmortem and preclinical research strongly implicates dysregulation of
glutamatergic neurotransmission in major depressive disorder (MDD). Recently …
glutamatergic neurotransmission in major depressive disorder (MDD). Recently …
Metabotropic glutamate receptor 5 binding and protein expression in schizophrenia and following antipsychotic drug treatment
Metabotropic glutamate receptor 5 (mGluR5) has been identified as a potential therapeutic
target for schizophrenia, primarily due to its ability to indirectly modulate glutamatergic …
target for schizophrenia, primarily due to its ability to indirectly modulate glutamatergic …
Metabotropic glutamatergic receptor 5 and stress disorders: knowledge gained from receptor imaging studies
The metabotropic glutamatergic receptor subtype 5 (mGluR5) may represent a promising
therapeutic target for stress-related psychiatric disorders. Here, we describe mGluR5 …
therapeutic target for stress-related psychiatric disorders. Here, we describe mGluR5 …
[PDF][PDF] Promise of mGluR2/3 activators in psychiatry
The group II metabotropic glutamate receptors (mGluRs), mGluR2 and mGluR3, have
emerged as exciting and well-validated targets for novel therapeutic agents used for treating …
emerged as exciting and well-validated targets for novel therapeutic agents used for treating …
The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia
PJ Harrison, L Lyon, LJ Sartorius… - Journal of …, 2008 - journals.sagepub.com
Group II metabotropic glutamate receptors (mGluRs) comprise mGluR2 (mGlu2; encoded by
GRM2) and mGluR3 (mGlu3; encoded by GRM3) and modulate glutamate …
GRM2) and mGluR3 (mGlu3; encoded by GRM3) and modulate glutamate …
Metabotropic glutamate receptor 5 in the pathology and treatment of schizophrenia
Metabotropic glutamate receptor 5 (mGluR5) potentiates the NMDA receptor (NMDAR) in
brain regions implicated in schizophrenia, making it a viable therapeutic target for the …
brain regions implicated in schizophrenia, making it a viable therapeutic target for the …
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