I. Introduction PAST studies of antidepressants have focused almost exclusively on their
effects on the metabolism and receptors of monoamine neurotransmitters in various brain …

Major alterations of the hypothalamic–pituitary–adrenocortical (HPA) system that can be
reversed by successful antidepressant therapy are often seen in depressed patients. …

Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage.
The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD …

The P2RX7 gene is located within a region on chromosome 12q24.31 that has been identified
as a susceptibility locus for affective disorders by linkage and association studies. P2RX7 …

Previous results from our genetic analyses using pedigrees from a French Canadian
population suggested that the interval delimited by markers on chromosome 12, D12S86 and …

GLUCOCORTICOIDS, in conjunction with their cognate receptors, exert negative-feedback
effects on the hypothalamus-pituitary-adrenal axis, suppressing adrenal steroid secretions. …

Major depression is associated with reduced hippocampal volume linked to stress and high
glucocorticoid secretion. Glucocorticoid receptor-impaired (GR-i) mice, a transgenic model …

We completed a genome‐wide scan for susceptibility loci for bipolar affective disorders in
families derived from a rather homogeneous population in the Province of Québec. The …

Impaired cognitive function and enhanced activity of the hypothalamic‐pituitary‐adrenocortical
system are among the cardinal symptoms of major depression in humans that resolve …

The possible implication of the amygdaloid central nucleus (ACE) of the rat in the control of
ACTH secretion in response to immobilization stress was assessed. The ACTH secretion, in …