[HTML][HTML] Hippocampal atrophy in major depression: a function of childhood maltreatment rather than diagnosis?
N Opel, R Redlich, P Zwanzger, D Grotegerd… - …, 2014 - nature.com
Reduced hippocampal volumes are probably the most frequently reported structural
neuroimaging finding associated with major depressive disorder (MDD). However, it remains …
neuroimaging finding associated with major depressive disorder (MDD). However, it remains …
[HTML][HTML] Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive …
…, D Grotegerd, U Dannlowski, V Arolt, N Opel… - Molecular …, 2017 - nature.com
The neuro-anatomical substrates of major depressive disorder (MDD) are still not well
understood, despite many neuroimaging studies over the past few decades. Here we present the …
understood, despite many neuroimaging studies over the past few decades. Here we present the …
[HTML][HTML] ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
…, U Lueken, A Nunes, JO Neill, N Opel… - Translational …, 2020 - nature.com
This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging
Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across …
Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across …
[HTML][HTML] ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing
A key objective in the field of translational psychiatry over the past few decades has been to
identify the brain correlates of major depressive disorder (MDD). Identifying measurable …
identify the brain correlates of major depressive disorder (MDD). Identifying measurable …
Mediation of the influence of childhood maltreatment on depression relapse by cortical structure: a 2-year longitudinal observational study
N Opel, R Redlich, K Dohm, D Zaremba… - The Lancet …, 2019 - thelancet.com
Background Childhood maltreatment is a leading environmental risk factor for an unfavourable
course of disease in major depressive disorder. Both maltreatment and major depressive …
course of disease in major depressive disorder. Both maltreatment and major depressive …
Cross-disorder analysis of brain structural abnormalities in six major psychiatric disorders: a secondary analysis of mega-and meta-analytical findings from the …
N Opel, J Goltermann, M Hermesdorf, K Berger… - Biological …, 2020 - Elsevier
Background Neuroimaging studies have consistently reported similar brain structural
abnormalities across different psychiatric disorders. Yet, the extent and regional distribution of …
abnormalities across different psychiatric disorders. Yet, the extent and regional distribution of …
Quantifying deviations of brain structure and function in major depressive disorder across neuroimaging modalities
Importance Identifying neurobiological differences between patients with major depressive
disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for …
disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for …
Genetic variants associated with longitudinal changes in brain structure across the lifespan
Human brain structure changes throughout the lifespan. Altered brain growth or rates of
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …
Brain morphometric biomarkers distinguishing unipolar and bipolar depression: a voxel-based morphometry–pattern classification approach
R Redlich, JR Almeida, D Grotegerd, N Opel… - JAMA …, 2014 - jamanetwork.com
Importance The structural abnormalities in the brain that accurately differentiate unipolar
depression (UD) and bipolar depression (BD) remain unidentified. Objectives First, to …
depression (UD) and bipolar depression (BD) remain unidentified. Objectives First, to …
Prediction of individual response to electroconvulsive therapy via machine learning on structural magnetic resonance imaging data
R Redlich, N Opel, D Grotegerd, K Dohm… - JAMA …, 2016 - jamanetwork.com
Importance Electroconvulsive therapy (ECT) is one of the most effective treatments for
severe depression. However, biomarkers that accurately predict a response to ECT remain …
severe depression. However, biomarkers that accurately predict a response to ECT remain …