The therapeutic role of 5-HT1A and 5-HT2A receptors in depression
The selective serotonin reuptake inhibitors (SSRIs) are the most frequently prescribed
antidepressant drugs, because they are well tolerated and have no severe side effects. They …
antidepressant drugs, because they are well tolerated and have no severe side effects. They …
Neurobiological mechanisms involved in antidepressant therapies
M Briley, C Moret - Clinical neuropharmacology, 1993 - journals.lww.com
Selective serotonin reuptake inhibitors (SSRIs) are effective in alleviating the symptoms of
depression. However, clinical improvement is only obtained after several weeks of …
depression. However, clinical improvement is only obtained after several weeks of …
Serotonergic targets in depression
DN Middlemiss, GW Price, JM Watson - Current opinion in pharmacology, 2002 - Elsevier
Serotonin reuptake inhibitors have proved to be a very effective treatment for depression
and have strengthened the hypothesis that impaired 5-hydroxytryptamine (5-HT) …
and have strengthened the hypothesis that impaired 5-hydroxytryptamine (5-HT) …
Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists
At clinically relevant doses, selective serotonin (5-HT) reuptake inhibitors (SSRIs) and MAO
inhibitors (MAOIs) increase the extracellular concentration of 5-HT in the midbrain raphé …
inhibitors (MAOIs) increase the extracellular concentration of 5-HT in the midbrain raphé …
Selective activation of postsynaptic 5-HT1A receptors induces rapid antidepressant response
P Blier, R Bergeron, C de Montigny - Neuropsychopharmacology, 1997 - Elsevier
It has been reported that the 5-HT1A autoreceptor antagonist pindolol can accelerate the
antidepressant response to the selective serotonin (5-HT) reuptake inhibitor (SSRI) …
antidepressant response to the selective serotonin (5-HT) reuptake inhibitor (SSRI) …
Serotonin 5-HT1A Receptors as Targets for Agents to Treat Psychiatric Disorders: Rationale and Current Status of Research
P Celada, A Bortolozzi, F Artigas - CNS drugs, 2013 - Springer
Psychiatric disorders represent a large economic burden in modern societies. However,
pharmacological treatments are still far from optimal. Drugs used in the treatment of major …
pharmacological treatments are still far from optimal. Drugs used in the treatment of major …
The role of serotonin receptor subtypes in treating depression: a review of animal studies
GV Carr, I Lucki - Psychopharmacology, 2011 - Springer
Abstract Rationale Serotonin reuptake inhibitors (SSRIs) are effective in treating depression.
Given the existence of different families and subtypes of 5-HT receptors, multiple 5-HT …
Given the existence of different families and subtypes of 5-HT receptors, multiple 5-HT …
Pharmacology of rapid-onset antidepressant treatment strategies
P Blier - Journal of Clinical Psychiatry, 2001 - psychiatrist.com
Although selective serotonin reuptake inhibitors (SSRIs) block serotonin (5-HT) reuptake
rapidly, their therapeutic action is delayed. The increase in synaptic 5-HT activates feedback …
rapidly, their therapeutic action is delayed. The increase in synaptic 5-HT activates feedback …
5‐HT1A and beyond: the role of serotonin and its receptors in depression and the antidepressant response
JF Cryan, BE Leonard - Human Psychopharmacology: Clinical …, 2000 - Wiley Online Library
Since its discovery 50 years ago, the role of the indoleamine 5‐HT (5‐hydroxytryptamine;
serotonin) in the pathogenesis of depression and in the mechanism of action of …
serotonin) in the pathogenesis of depression and in the mechanism of action of …
Serotonin receptors involved in antidepressant effects
F Artigas - Pharmacology & therapeutics, 2013 - Elsevier
The neurotransmitter serotonin (5-hdroxytryptamine; 5-HT) has been implicated in the
pathophysiology and treatment of major depression since the serendipitous discovery of …
pathophysiology and treatment of major depression since the serendipitous discovery of …
