Mild cognitive impairment is a syndrome defined as cognitive decline greater than expected
for an individual's age and education level but that does not interfere notably with activities …

The construct of mild cognitive impairment ( MCI ) has evolved over the past 10 years since
the publication of the new MCI definition at the K ey S ymposium in 2003, but the core criteria …

The NINCDS–ADRDA and the DSM-IV-TR criteria for Alzheimer's disease (AD) are the
prevailing diagnostic standards in research; however, they have now fallen behind the …

In the past 8 years, both the International Working Group (IWG) and the US National Institute
on Aging–Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's …

During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD)
considering the disease as a continuum. Thanks to evolving biomarker research and …

Dementia has been increasingly more recognized to be a common feature in patients with
Parkinson's disease (PD), especially in old age. Specific criteria for the clinical diagnosis of …

Background Leuco-methylthioninium bis(hydromethanesulfonate; LMTM), a stable reduced
form of the methylthioninium moiety, acts as a selective inhibitor of tau protein aggregation …

An estimated 24 million people worldwide have dementia, the majority of whom are thought
to have Alzheimer's disease. Thus, Alzheimer's disease represents a major public health …

Alzheimer's disease (AD) is classically defined as a dual clinicopathological entity. The recent
advances in use of reliable biomarkers of AD that provide in-vivo evidence of the disease …

Cerebrovascular disease is the second most common cause of acquired cognitive impairment
and dementia and contributes to cognitive decline in the neurodegenerative dementias. …