Background Monitoring of white cell counts during clozapine treatment leads to cessation of
therapy if levels fall below pre-determined values. Reductions in white cell counts, driven by …

Background Clozapine (CLZ) is used for treatment-resistant schizophrenia (TRS). Adverse
reactions to clozapine include neutropenia. In March 2020, WHO declared the COVID-19 …

Clozapine is associated with haematological side effects, including neutropaenia, which can
signal impending life-threatening agranulocytosis. Patients with COVID-19 infection …

Background Clozapine is among the most effective antipsychotics used for treatment
resistant schizophrenia. Adverse reactions to clozapine include neutropenia. In March 2020 …

People with mental health disorders are at increased risk for coronavirus disease 2019
(COVID-19) and its severe complications, including a high mortality rates, compared to the …

Background: Clozapine is the only approved antipsychotic for treatment-resistant
schizophrenia. Despite its therapeutic benefits, it is still widely underused, mainly because of …

We compliment the authors and journal for ensuring the “Consensus statement on the use of
clozapine during the COVID-19 pandemic” was published in a timely fashion. 1 Coronavirus …

Clozapine is the only available treatment for refractory schizophrenia but its use involves
frequent physical contact with healthcare workers for the purpose of mandatory blood …

There is both uncertainty regarding the safety of clozapine in COVID-19 patients owing to
limited published data and a lack of consensus on continuing clozapine in patients with …

Clozapine is mainly metabolized by the cytochrome P450 1A2 (CYP1A2) leading to its main
metabolite, norclozapine. 1 Clozapine metabolism is influenced by 3 levels of complexity:(1) …