Bioactive contaminants leach from disposable laboratory plasticware
GR McDonald, AL Hudson, SMJ Dunn, H You… - Science, 2008 - science.org
Disposable plasticware such as test tubes, pipette tips, and multiwell assay or culture plates
are used routinely in most biological research laboratories. Manufacturing of plastics …
are used routinely in most biological research laboratories. Manufacturing of plastics …
Atomic force microscopy reveals the stoichiometry and subunit arrangement of the α4β3δ GABAA receptor
…, H You, RM Henderson, IL Martin, SMJ Dunn… - Molecular …, 2008 - ASPET
The GABA A receptor is a chloride-selective ligand-gated ion channel of the Cys-loop superfamily.
The receptor consists of five subunits arranged pseudosymmetrically around a central …
The receptor consists of five subunits arranged pseudosymmetrically around a central …
The Major Site of Photoaffinity Labeling of the γ-Aminobutyric Acid Type A Receptor by [3H] Flunitrazepam Is Histidine 102 of the α Subunit (∗)
…, MR Carpenter, LB Smillie, IL Martin, SMJ Dunn - Journal of Biological …, 1996 - ASBMB
The α subunit of the γ-aminobutyric acid type A (GABA A ) receptor is known to be photoaffinity
labeled by the classical benzodiazepine agonist, [ 3 H]flunitrazepam. To identify the …
labeled by the classical benzodiazepine agonist, [ 3 H]flunitrazepam. To identify the …
Insights into the structure and pharmacology of GABAA receptors
CRJ Carter, JL Kozuska, SMJ Dunn - Future medicinal chemistry, 2010 - Future Science
GABA is the major inhibitory neurotransmitter in the adult mammalian CNS. The ionotropic
GABA type A receptors (GABA A Rs) belong to the Cys-loop family of receptors. Each member …
GABA type A receptors (GABA A Rs) belong to the Cys-loop family of receptors. Each member …
Identification of a residue in the γ‐aminobutyric acid type A receptor α subunit that differentially affects diazepam‐sensitive and‐insensitive benzodiazepine site …
JMC Derry, SMJ Dunn, M Davies - Journal of neurochemistry, 2004 - Wiley Online Library
GABA A receptors that contain either the α4‐ or α6‐subunit isoform do not recognize classical
1,4‐benzodiazepines (BZDs). However, other classes of BZD site ligands, including β‐…
1,4‐benzodiazepines (BZDs). However, other classes of BZD site ligands, including β‐…
Molecular neurobiology of the GABAA receptor
SMJ Dunn, AN Bateson, IL Martin - International review of neurobiology, 1994 - Elsevier
Publisher Summary This chapter discusses the molecular neurobiology of the GABA A
receptor. The GABA A receptor is responsible for the majority of neuronal inhibition in the …
receptor. The GABA A receptor is responsible for the majority of neuronal inhibition in the …
Kinetics of substrate, coenzyme, and inhibitor binding to Escherichia coli dihydrofolate reductase
PJ Cayley, SMJ Dunn, RW King - Biochemistry, 1981 - ACS Publications
P. Jane Cayley, 1 Susan MJ Dunn, 8 and Rodney W. King* abstract: Reduced nicotinamide
adenine dinucleotide phosphate (NADPH), folate, dihydrofolate, and the inhibitors …
adenine dinucleotide phosphate (NADPH), folate, dihydrofolate, and the inhibitors …
Structural Requirements for Ligand Interactions at the Benzodiazepine Recognition Site of the GABAA Receptor
M Davies, AN Bateson, SMJ Dunn - Journal of neurochemistry, 1998 - Wiley Online Library
His 101 of the GABA A receptor α1 subunit is an important determinant of benzodiazepine
recognition and a major site of photolabeling by [ 3 H]flunitrazepam. To investigate further the …
recognition and a major site of photolabeling by [ 3 H]flunitrazepam. To investigate further the …
Mutagenesis of the rat α1 subunit of the γ-aminobutyric acidA receptor reveals the importance of residue 101 in determining the allosteric effects of benzodiazepine …
SMJ Dunn, M Davies, AL Muntoni, JJ Lambert - Molecular pharmacology, 1999 - ASPET
The γ-aminobutyric acid A (GABA A ) receptor contains a binding site (or sites) for
benzodiazepines and related ligands. Previous studies have shown that the residue occupying …
benzodiazepines and related ligands. Previous studies have shown that the residue occupying …
Characterization of the interaction of zopiclone with γ-aminobutyric acid type A receptors
…, JG Newell, JMC Derry, IL Martin, SMJ Dunn - Molecular …, 2000 - ASPET
Zopiclone is a cyclopyrrolone that is used clinically as a hypnotic. Although this drug is known
to interact with neuronal γ-aminobutyric acid type A receptors, its binding site(s) within the …
to interact with neuronal γ-aminobutyric acid type A receptors, its binding site(s) within the …