Awareness of the metabolism of second-generation antipsychotics by the cytochrome P450
(CYP) system can inform the clinician about how to avoid and manage drug–drug …

The involvement of cytochrome P450 (CYP) enzymes in the metabolism of the atypical
(secondgeneration) antipsychotics clozapine, risperidone, olanzapine, quetiapine …

The introduction of the atypical antipsychotics clozapine, risperidone, olanzapine,
quetiapine and sertindole for the treatment of schizophrenia has coincided with an …

Newer antipsychotics introduced in clinical practice in recent years include clozapine,
risperidone, olanzapine, quetiapine, sertindole, ziprasidone, aripiprazole and amisulpride …

Many antipsychotics, including perphenazine, zuclopenthixol, thioridazine, haloperidol and
risperidone, are metabolised to a significant extent by the polymorphic cytochrome P450 …

Objectives: While not always clinically significant, patients with schizophrenia may be at risk
for drug (drug–interactions (DDIs) with second-generation antipsychotics. Second …

This paper reviews the current literature describing the metabolism of both multi-receptor
clozapine analogue atypical antipsychotic drugs (clozapine, olanzapine, and quetiapine) …

Drug-drug interactions or genetic variability may require using doses different from those
recommended for atypical antipsychotics. Dosage alterations of olanzapine and clozapine …

1 The ability of olanzapine to inhibit the metabolism of marker catalytic activities for the
cytochromes P450 CYP3A, CYP2D6, CYP2C9, and CYP2C19 was examined. This …

Despite the introduction of newer drugs, the atypical antipsychotic clozapine remains the
most effective drug in psychotic patients who are resistant to treatment with conventional …