Background The efficacy of corticosteroids in reducing the incidence of postextubation
laryngeal oedema is controversial. We aimed to test our hypothesis that methylprednisolone …

Background To address the unmet medical need for an effective prophylactic vaccine
against Ebola virus we assessed the safety and immunogenicity of three different two-dose …

Rationale: Intensive care unit (ICU) beds are a scarce resource, and patients denied intensive
care only because the unit is full may be at increased risk of death. Objective: To compare …

Importance Sirolimus is increasingly being used to treat various vascular anomalies, although
evidence of its efficacy is lacking. Objective To assess the efficacy and safety of sirolimus …

OBJECTIVES To determine the accuracy of bedside glucose strip assay on capillary blood
and on whole blood and to identify factors predictive of discrepancies with the laboratory …

Objective To compare the initial (D7) calorie intake and tolerability of two early enteral nutrition
protocols in which the optimal flow rate was introduced either immediately or gradually. …

Objective To analyze the influence of severe obesity on mortality and morbidity in mechanically
ventilated intensive care unit (ICU) patients. Design Prospective, multi-center exposed/…

The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC)
COVID-19 dataset is one of the largest international databases of prospectively collected …

Purpose Positron emission tomography (PET) imaging of brain amyloid load has been
suggested as a core biomarker for Alzheimer’s disease (AD). The aim of this study was to test the …

Clonal hematopoiesis (CH) of indeterminate potential has been described in blood samples
from large series of patients. Its prevalence and consequences are still not well understood …