User profiles for Xuezhu Cai

Xuezhu Cai

Northeastern University
Verified email at husky.neu.edu
Cited by 532

[HTML][HTML] Data on MRI brain lesion segmentation using K-means and Gaussian Mixture Model-Expectation Maximization

J Qiao, X Cai, Q Xiao, Z Chen, P Kulkarni, C Ferris… - Data in brief, 2019 - Elsevier
The data in this article provide details about MRI lesion segmentation using K-means and
Gaussian Mixture Model-Expectation Maximization (GMM-EM) algorithms. Both K-means and …

[HTML][HTML] Inhaled cannabis suppresses chemotherapy-induced neuropathic nociception by decoupling the raphe nucleus: a functional imaging study in rats

…, AR Miller, AG Hohmann, AH Sadaka, X Cai… - Biological Psychiatry …, 2021 - Elsevier
Background Efficacy of inhaled cannabis for treating pain is controversial. Effective
treatment for chemotherapy-induced neuropathy represents an unmet medical need. We …

Imaging the effect of the circadian light–dark cycle on the glymphatic system in awake rats

X Cai, J Qiao, P Kulkarni, IC Harding… - Proceedings of the …, 2020 - National Acad Sciences
The glymphatic system functions in the removal of potentially harmful metabolites and proteins
from the brain. Dynamic, contrast-enhanced MRI was used in fully awake rats to follow the …

Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma

…, X Da, Y Ou, KE Emblem, A Muzikansky, X Cai… - Journal of neuro …, 2017 - Springer
Targeting tumor angiogenesis is a potential therapeutic strategy for glioblastoma because
of its high vascularization. Tivozanib is an oral pan-VEGF receptor tyrosine kinase inhibitor …

Altered corticolimbic connectivity reveals sex-specific adolescent outcomes in a rat model of early life adversity

…, C Demaestri, S Peterzell, MM Silveri, X Cai… - Elife, 2020 - elifesciences.org
Exposure to early-life adversity (ELA) increases the risk for psychopathologies associated
with amygdala-prefrontal cortex (PFC) circuits. While sex differences in vulnerability have …

[HTML][HTML] Neuroradiological changes following single or repetitive mild TBI

P Kulkarni, TR Morrison, X Cai, S Iriah… - Frontiers in systems …, 2019 - frontiersin.org
Objectives To test the hypothesis that there are differences in neuroradiological measures
between single and repeated mild traumatic brain injury using multimodal MRI. Methods A …

In search of early neuroradiological biomarkers for Parkinson's Disease: Alterations in resting state functional connectivity and gray matter microarchitecture in PINK1 …

X Cai, JU Qiao, T Knox, S Iriah, P Kulkarni, D Madularu… - Brain Research, 2019 - Elsevier
Parkinson’s Disease (PD) is the second most common neurodegenerative disorder, with
60,000 new cases diagnosed each year in the US. There are multiple animal models of PD that …

Mild repetitive head impacts alter perivascular flow in the midbrain dopaminergic system in awake rats

X Cai, IC Harding, AH Sadaka, B Colarusso… - Brain …, 2021 - academic.oup.com
Head injury is a known risk factor for Parkinson’s disease. Disruption in the perivascular
clearance of metabolic waste and unwanted proteins is thought to be a contributing factor to …

[HTML][HTML] Alterations in brain neurocircuitry following treatment with the chemotherapeutic agent paclitaxel in rats

CF Ferris, S Nodine, T Pottala, X Cai, TM Knox… - Neurobiology of Pain, 2019 - Elsevier
Human and animal studies suggest that both traumatic nerve injury and toxic challenge with
chemotherapeutic agents involves the reorganization of neural circuits in the brain. However…

ABCD1 dysfunction alters white matter microvascular perfusion

A Lauer, X Da, MB Hansen, G Boulouis, Y Ou, X Cai… - Brain, 2017 - academic.oup.com
Cerebral X-linked adrenoleukodystrophy is a devastating neurodegenerative disorder
caused by mutations in the ABCD1 gene, which lead to a rapidly progressive cerebral …