Objectives: Myo‐inositol is an important component of the phosphatidylinositol second
messenger system (PI‐cycle). Alterations in PI‐cycle activity have been suggested to be …

In haemophilia patients, a relationship is usually observed between the clinical expression
of the disease and plasmatic factor VIII/factor IX (FVIII/FIX) activity. However, it is known from …

Valproic acid has been used to treat mania and bipolar disorder, but its mechanism of action
is not agreed on. We used rat genome U34A Affymetrix oligonucleotide microarrays …

Although lithium is still a mainstay in the treatment of bipolar disorder, its underlying
mechanisms of action have not been completely elucidated. Several studies have shown …

SUMMARY A full-length serotonin receptor mRNA from the 5Hthpr gene was sequenced
from larvae of the sea urchin, Hemicentrotus pulcherrimus. The DNA sequence was most …

Psychiatric manifestations of primary hyperparathyroidism are mediated by hypercalcemia.
To date, most evidence indicates that hypercalcemia and increased cerebrospinal-fluid …

Octave-circular pitch perception, the repetition of pitch scale qualities when surpassing the
octave interval, has been observed in behavioral data from humans and monkeys, but the …

The chronic use of opioids is often accompanied by the development of tolerance and/or
dependence upon these agents due to the adaptive changes in the response of the subject …

Carbamazepine (CBZ) has long been a therapeutic option for bipolar disorder.
Carbamazepine extended-release capsules (CBZ-ERC) are a recent formulation of CBZ …

Juvenile myoclonic epilepsy (JME) is the most frequent cause of hereditary grand mal
seizures. We previously mapped and narrowed a region associated with JME on …