Originally published in February 2004. This guideline is more than 5 years old and has not
yet been updated to ensure that it reflects current knowledge and practice. In accordance …

The importance of reviewing and studying sex-based differences in pharmacologic
parameters is demonstrated by the increasing data on gender variation in drug efficacy and …

The liver is critical to consider during drug development because of its central role in the
handling of xenobiotics, a process which often leads to localized and/or downstream tissue …

Many drugs have been associated with QTc prolongation and, in some cases, this is
augmented by concomitant administration with metabolic inhibitors. The effects of 6 …

Medicinal cannabis use has increased exponentially with widespread legalization around
the world. Cannabis-based products are being used for numerous health conditions, often in …

The last decade of research into the pharmacogenetics of antipsychotics has seen the
development of genetic tests to determine the patients' metabolic status and the first attempts …

The use of second‐generation antipsychotics (SGAs) is associated with metabolic side
effects including weight gain, diabetes mellitus and an atherogenic lipid profile. These …

These guidelines for the biological treatment of schizophrenia were developed by an
international Task Force of the World Federation of Societies of Biological Psychiatry …

Newer antipsychotics introduced in clinical practice in recent years include clozapine,
risperidone, olanzapine, quetiapine, sertindole, ziprasidone, aripiprazole and amisulpride …

The involvement of cytochrome P450 (CYP) enzymes in the metabolism of the atypical
(secondgeneration) antipsychotics clozapine, risperidone, olanzapine, quetiapine …