The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

▪ Abstract Opioid receptors belong to the large superfamily of seven transmembrane-
spanning (7TM) G protein-coupled receptors (GPCRs). As a class, GPCRs are of …

Single-cell RNA sequencing offers a promising opportunity for probing cell types mediating
specific behavioral functions and the underlying molecular programs. However, this has …

Mood disorders are serious diseases that affect a large portion of the population. There have
been many hypotheses put forth over the years to explain the development of major …

Decreased medial prefrontal cortex (mPFC) neuronal activity is associated with social defeat-
induced depression-and anxiety-like behaviors in mice. However, the molecular …

Depression is one of the most prevalent forms of mental disorders and is the most common
cause of disability in the Western world. Besides, the harmful effects of stress-related mood …

Cannabinoid agonists induce complex and often contradictory effects on anxiety in humans
and experimental animals. The data from animal tests provide evidence of dose-dependent …

Evidence for the involvement of the endocannabinoid system (ECS) in anxiety and fear has
been accumulated, providing leads for novel therapeutic approaches. In anxiety, a …

In recent years, studies have advocated neuropeptide systems as modulators for the
behavioral states found in mood disorders such as depression and anxiety disorders …

The hippocampus is broadly impacted by neuromodulations. However, how neuropeptides
shape the function of the hippocampus and the related spatial learning and memory remains …