Psychiatric disorders and leukocyte telomere length: underlying mechanisms linking mental illness with cellular aging

D Lindqvist, ES Epel, SH Mellon, BW Penninx… - Neuroscience & …, 2015 - Elsevier
Many psychiatric illnesses are associated with early mortality and with an increased risk of
developing physical diseases that are more typically seen in the elderly. Moreover, certain …

Telomeres and early-life stress: an overview

LH Price, HT Kao, DE Burgers, LL Carpenter… - Biological …, 2013 - Elsevier
The long-term sequelae of adverse early-life experiences have long been a focus in
psychiatry, with a historic neurobiological emphasis on physiological systems that are …

Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study

I Shalev, TE Moffitt, K Sugden, B Williams… - Molecular …, 2013 - nature.com
There is increasing interest in discovering mechanisms that mediate the effects of childhood
stress on late-life disease morbidity and mortality. Previous studies have suggested one …

The association between psychiatric disorders and telomere length: a meta-analysis involving 14,827 persons

SM Darrow, JE Verhoeven, D Révész… - Psychosomatic …, 2016 - journals.lww.com
Objective This study examined the relationship between leukocyte telomere length (LTL), a
marker of cell aging, and psychiatric disorders in adults compared with controls using meta …

Oxidative stress in anxiety and comorbid disorders

I Hovatta, J Juhila, J Donner - Neuroscience research, 2010 - Elsevier
Anxiety disorders, depression, and alcohol use disorder are common neuropsychiatric
diseases that often occur together. Oxidative stress has been suggested to contribute to their …

Alterations of mitochondrial DNA copy number and telomere length with early adversity and psychopathology

AR Tyrka, SH Parade, LH Price, HT Kao, B Porton… - Biological …, 2016 - Elsevier
Background Telomere shortening and alterations of mitochondrial biogenesis are involved
in cellular aging. Childhood adversity is associated with telomere shortening, and several …

Childhood exposure to violence and lifelong health: Clinical intervention science and stress-biology research join forces

TE Moffitt - Development and psychopathology, 2013 - cambridge.org
Many young people who are mistreated by an adult, victimized by bullies, criminally
assaulted, or who witness domestic violence react to this violence exposure by developing …

Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls

L Kananen, I Surakka, S Pirkola, J Suvisaari… - PloS one, 2010 - journals.plos.org
Accelerated leukocyte telomere shortening has been previously associated to self-perceived
stress and psychiatric disorders, including schizophrenia and mood disorders. We set out to …

Accelerating research on biological aging and mental health: Current challenges and future directions

LKM Han, JE Verhoeven, AR Tyrka… - …, 2019 - Elsevier
Aging is associated with complex biological changes that can be accelerated, slowed, or
even temporarily reversed by biological and non-biological factors. This article focuses on …

Systemic biomarkers of accelerated aging in schizophrenia: a critical review and future directions

TT Nguyen, LT Eyler, DV Jeste - Schizophrenia bulletin, 2018 - academic.oup.com
Background: Schizophrenia is associated with increased physical morbidity and early
mortality, suggesting that the aging process may be accelerated in schizophrenia. However …