Substance use disorders occur commonly in patients with schizophrenia and dramatically
worsen their overall clinical course. While the exact mechanisms contributing to substance …

Noncoding variants play a central role in the genetics of complex traits, but we still lack a full
understanding of the molecular pathways through which they act. We quantified the …

Patients with schizophrenia are at an increased risk for the development of depression.
Overlap in the symptoms and genetic risk factors between the two disorders suggests a …

Catechol‐O‐methyltransferase (COMT) Val158Met is widely regarded as potentially
important for understanding the genetic etiology of many different psychiatric disorders. The …

Much remains to be learned about the etiology of obsessive‐compulsive disorder (OCD).
Twin studies suggest that it arises from both disorder‐specific and non‐specific genetic …

Abstract Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation
of catechol substrates, classically in catecholamine metabolism, but also acting upon other …

Purpose Although exercise and sleep duration habits are associated with cognitive function,
their beneficial effects on cognitive function remain unclear. We aimed to examine the effect …

In schizophrenia, genetic and environmental factors affect neurodevelopment and
neuroprogressive trajectory. Altered expression of neuro-immune genes and increased …

Most people are right-handed and show left-hemispheric language lateralization, but a
minority exhibits left-handedness and right-hemispheric language lateralization. This …

Background The shortened life expectancy in schizophrenia (SCZ) patients may be
correlated with most cancers, yet there is heterogeneity in the studies examining these …