Context.—Immunohistochemistry has taken a central role in the field of pathology, and its
role is destined to increase as companion diagnostics analogous to the HercepTest are …

The main respiratory muscles are not capable of rhythmic or voluntary contraction when the
upper cervical spinal cord is transected. In contrast, in many other automatic organ systems …

The clinical development of an inhibitor of cellular proteasome function suggests that compounds
targeting other components of the ubiquitin–proteasome system might prove useful for …

Systematic analyses of cancer genomes promise to unveil patterns of genetic alterations
linked to the genesis and spread of human cancers. High-density single-nucleotide …

We present current concepts and evidence to optimize diagnosis and management of
osteoarthritis in the thumb joints. Numerous options and controversies exist for surgical treatment …

Affymetrix and spotted oligonucleotide microarrays were used to assess global differential
gene expression comparing normal human melanocytes with six independent melanoma cell …

This study demonstrates that in malignant melanoma, elevated levels of nuclear ß-catenin
in both primary tumors and metastases correlate with reduced expression of a marker of …

… The authors gratefully acknowledge postdoctoral fellowships: AJ Berger from the George
E. Hewitt Foundation for Medical Research; F. Bevilacqua from the Swiss National Science …

We demonstrate the use of Raman spectroscopy to measure the concentration of many
important constituents (analytes) in serum and whole blood samples at physiological …

RATIONALE AND OBJECTIVES: Near-infrared (NIR) diffuse optical spectroscopy and imaging
may enhance existing technologies for breast cancer screening, diagnosis, and treatment…