Altered cerebral connectivity is one of the core pathophysiological mechanism underlying the
development and progression of information-processing deficits in schizophrenia. To date, …

Negative symptoms such as anhedonia and apathy are among the most debilitating manifestations
of schizophrenia (SZ). Imaging studies have linked these symptoms to morphometric …

Long-acting injectable antipsychotics (LAIs) offer many benefits to patients with schizophrenia
spectrum disorder (SSD). They are used with very different frequencies due to questions …

Background: Striatal dysfunction has been proposed as a pathomechanism for negative
symptoms in schizophrenia. There is consensus that negative symptoms can be grouped into 2 …

Background Disruptive and aggressive behavior is frequent in patients with a psychotic
disorder; furthermore, it is a recurrent reason for compulsory admission. Even during treatment, …

Background A growing body of neuroimaging research has revealed a relationship between
blunted activation of the ventral striatum (VS) and apathy in schizophrenia. In contrast, the …

Negative symptoms in schizophrenia remain a challenge with limited therapeutic strategies.
The novel compound RG7203 promotes reward learning via dopamine D1-dependent …

Background Primary and secondary negative symptoms (NS) are core features of schizophrenia
(SCZ) and can also be observed in bipolar-disorder-I (BD-I) patients. Secondary NS, …

Background and objective: Psychotic disorders are among the top causes of disability
worldwide. Guidelines emphasizes the need for research to tailor psychotherapeutic approaches …

Background: Negative symptoms are currently viewed as having a 2-dimensional structure,
with factors reflecting diminished expression (EXP) and motivation and pleasure (MAP). …