Mechanisms of the free fatty acid-induced increase in hepatic glucose production

…, G van de Werve, IG Fantus, A Giacca - American Journal …, 2003 - journals.physiology.org
The associations between obesity, insulin resistance, and type 2 diabetes mellitus are well
documented. Free fatty acids (FFA), which are often elevated in obesity, have been …

Free fatty acid–induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo

…, M Rozakis-Adcock, MB Wheeler, A Giacca - Diabetes, 2007 - Am Diabetes Assoc
OBJECTIVE—An important mechanism in the pathogenesis of type 2 diabetes in obese
individuals is elevation of plasma free fatty acids (FFAs), which induce insulin resistance and …

Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes

GF Lewis, A Carpentier, K Adeli, A Giacca - Endocrine reviews, 2002 - academic.oup.com
The primary genetic, environmental, and metabolic factors responsible for causing insulin
resistance and pancreatic β-cell failure and the precise sequence of events leading to the …

NOD1 activators link innate immunity to insulin resistance

…, MD Fullerton, Z Liu, GR Steinberg, A Giacca… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Insulin resistance associates with chronic inflammation, and participatory elements
of the immune system are emerging. We hypothesized that bacterial elements acting on …

Muscle-specific Pten deletion protects against insulin resistance and diabetes

…, M Eweida, C Jefferies, N Liadis, A Giacca… - … and cellular biology, 2005 - Taylor & Francis
Pten (phosphatase with tensin homology), a dual-specificity phosphatase, is a negative
regulator of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. Pten regulates a vast …

Mechanisms linking diet and colorectal cancer: the possible role of insulin resistance

WR Bruce, TMS Wolever, A Giacca - Nutrition and cancer, 2000 - Taylor & Francis
Diet is clearly implicated in the origin of colorectal cancer, with risk factors for the disease
including reduced consumption of vegetables, fiber, and starch and increased consumption of …

Possible mechanisms relating diet and risk of colon cancer

WR Bruce, A Giacca, A Medline - Cancer Epidemiology Biomarkers & …, 2000 - AACR
Two recent developments in cancer epidemiology and experimental carcinogenesis
provide the basis for two possible mechanisms relating diet and colon cancer risk. The first …

[HTML][HTML] Carnosic acid attenuates the free fatty acid-induced insulin resistance in muscle cells and adipocytes

DJ Den Hartogh, F Vlavcheski, A Giacca… - Cells, 2022 - mdpi.com
Elevated blood free fatty acids (FFAs), as seen in obesity, impair insulin action leading to
insulin resistance and Type 2 diabetes mellitus. Several serine/threonine kinases including JNK…

[HTML][HTML] The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species

Y Lin, AH Berg, P Iyengar, TKT Lam, A Giacca… - Journal of biological …, 2005 - ASBMB
Hyperglycemia is a major independent risk factor for diabetic macrovascular disease. The
consequences of exposure of endothelial cells to hyperglycemia are well established. …

Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation

…, B Lamarche, RN Bergman, A Giacca… - American Journal …, 1999 - journals.physiology.org
The in vivo effect of elevated free fatty acids (FFA) on β-cell function in humans remains
extremely controversial. We examined, in healthy young men, the acute (90 min) and chronic (48 …