User profiles for Aida Mohammadkhani

Aida Mohammadkhani

University of Calgary, Canada
Verified email at ucalgary.ca
Cited by 144

Orexin-1 receptor signaling in ventral pallidum regulates motivation for the opioid remifentanil

A Mohammadkhani, JE Fragale… - Journal of …, 2019 - Soc Neuroscience
Signaling at the orexin-1 receptor (OxR1) is important for motivated drug taking. Using a
within-session behavioral economics (BE) procedure, we previously found that pharmacologic …

Persistent effects of the orexin-1 receptor antagonist SB-334867 on motivation for the fast acting opioid remifentanil

A Mohammadkhani, MH James, CB Pantazis… - Brain research, 2020 - Elsevier
The orexin (hypocretin) system is multifaceted, and regulates sleep-wake cycles, nociception,
endocrine function and reward-seeking behavior. We have established an important role …

Identification of a potent human trace amine-associated receptor 1 antagonist

…, MF Brackeen, A Mohammadkhani… - ACS chemical …, 2022 - ACS Publications
Human trace amine-associated receptor subtype 1 (hTAAR1) is a G protein-coupled receptor
that has therapeutic potential for multiple diseases, including schizophrenia, drug addiction…

[HTML][HTML] Optogenetic stimulation of lateral hypothalamic orexin/dynorphin inputs in the ventral tegmental area potentiates mesolimbic dopamine neurotransmission …

CS Thomas, A Mohammadkhani, M Rana… - …, 2022 - nature.com
Reward and reinforcement processes are critical for survival and propagation of genes.
While numerous brain systems underlie these processes, a cardinal role is ascribed to …

Cellular and behavioral basis of cannabinioid and opioid interactions: implications for opioid dependence and withdrawal

A Mohammadkhani, SL Borgland - Journal of Neuroscience …, 2022 - Wiley Online Library
The brain's endogenous opioid and endocannabinoid systems are neuromodulatory of synaptic
transmission, and play key roles in pain, memory, reward, and addiction. Recent clinical …

Characterization of dopaminergic projections from the ventral tegmental area and the dorsal raphe nucleus to the orbital frontal cortex

DJ Noble, A Mohammadkhani, M Qiao… - European Journal of …, 2023 - Wiley Online Library
The orbitofrontal cortex (OFC) is a key node in the cortico‐limbic‐striatal circuitry that
influences decision‐making guided by the relative value of outcomes. Midbrain dopamine from …

Food for thought: diet-induced impairments to decision-making and amelioration by N-Acetylcysteine in male rats

S Becchi, J Hood, MD Kendig, A Mohammadkhani… - …, 2022 - Springer
Rationale Attempts to lose weight often fail despite knowledge of the health risks associated
with obesity and determined efforts. We previously showed that rodents fed an obesogenic …

[PDF][PDF] Neurons in the ventral striatopallidal complex modulate lateral hypothalamic orexin/hypocretin neuron activity: Implications for reward-seeking

CS Mitchell, A Mohammadkhani, EE Manning… - bioRxiv, 2020 - scholar.archive.org
Feeding is at once both a basic biological need and a function set in a complex system of
competing motivational drivers. Orexin/hypocretin neurons are located exclusively within the …

Chemogenetic stimulation of a retinal circuit activates brain noradrenergic neurons, prevents apoptosis and suppresses depression-like behaviors

HE Bowrey, MH James, M Omrani, A Mohammadkhani… - bioRxiv, 2021 - biorxiv.org
A chronically dysregulated locus coeruleus (LC) system gives rise to mood disorders. In
particular, prolonged LC hyperactivity often underlies stress disorders, whereas chronically …

Orexin-1 receptor signaling in ventral pallidum mediates demand for the opioid remifentanil

A Mohammadkhani, CB Pantazis, HE Bowrey… - bioRxiv, 2018 - biorxiv.org
Signaling at the orexin-1 receptor (Ox1R) is important for motivation for various drugs of abuse.
Recently, our laboratory showed that systemic blockade of Ox1Rs decreased motivation …