User profiles for Alexander McGirr

Alexander McGirr

University of Calgary
Verified email at ucalgary.ca
Cited by 6047

Safety and efficacy of adjunctive second-generation antidepressant therapy with a mood stabiliser or an atypical antipsychotic in acute bipolar depression: a …

A McGirr, PA Vöhringer, SN Ghaemi, RW Lam… - The Lancet …, 2016 - thelancet.com
Background Although mania and hypomania define bipolar disorder, depressive episodes
are more common and impairing, with few proven treatments. Adjunctive therapy with second-…

Dysregulation of the sympathetic nervous system, hypothalamic–pituitary–adrenal axis and executive function in individuals at risk for suicide

A McGirr, G Diaconu, MT Berlim, JC Pruessner… - Journal of Psychiatry and …, 2010 - jpn.ca
Background: Suicidal behaviour aggregates in families, and the hypothalamic–pituitary–adrenal
(HPA) axis and noradrenergic dysregulation may play a role in suicide risk. It is unclear …

Repetitive transcranial magnetic stimulation (rTMS) for treating major depression and schizophrenia: a systematic review of recent meta-analyses

CL Hovington, A McGirr, M Lepage… - Annals of medicine, 2013 - Taylor & Francis
Background. In recent years, repetitive transcranial magnetic stimulation (rTMS) has been
developed for the treatment of major depression (MD) and schizophrenia. Although rTMS has …

Impulsive-aggressive behaviours and completed suicide across the life cycle: a predisposition for younger age of suicide

A McGirr, J Renaud, A Bureau, M Seguin… - Psychological …, 2008 - cambridge.org
BackgroundIt is unclear whether the association between impulsive-aggressive behaviours
and suicide exists across different ages.MethodVia psychological autopsy, we examined a …

[HTML][HTML] Specific inhibition of phosphodiesterase-4B results in anxiolysis and facilitates memory acquisition

A McGirr, TV Lipina, HS Mun, J Georgiou… - …, 2016 - nature.com
Cognitive dysfunction is a core feature of dementia and a prominent feature in psychiatric
disease. As non-redundant regulators of intracellular cAMP gradients, phosphodiesterases (…

Effects of low-dose and very low-dose ketamine among patients with major depression: a systematic review and meta-analysis

…, N Glozier, P Glue, K Lapidus, A McGirr… - International Journal …, 2016 - academic.oup.com
Background: Several recent trials indicate low-dose ketamine produces rapid antidepressant
effects. However, uncertainty remains in several areas: dose response, consistency across …

Risk factors for suicide completion in borderline personality disorder: a case-control study of cluster B comorbidity and impulsive aggression.

A McGirr, J Paris, A Lesage, J Renaud… - Journal of Clinical …, 2007 - psychiatrist.com
Background: Borderline personality disorder is a major risk factor for suicidal behavior, yet
prediction of suicide completion remains unclear. It has been proposed that impulsivity and …

Current psychiatric morbidity, aggression/impulsivity, and personality dimensions in child and adolescent suicide: a case-control study

J Renaud, MT Berlim, A McGirr, M Tousignant… - Journal of affective …, 2008 - Elsevier
OBJECTIVE: The present study was designed to evaluate psychiatric risk factors for child
and adolescent suicide, and to determine the association between impulsive-aggressive and …

An examination of DSM-IV depressive symptoms and risk for suicide completion in major depressive disorder: a psychological autopsy study

A McGirr, J Renaud, M Seguin, M Alda… - Journal of affective …, 2007 - Elsevier
BACKGROUND: It is unclear whether certain DSM-IV depressive symptoms are more prevalent
among individuals who die in the context of a major depressive episode and those who …

Familial aggregation of suicide explained by cluster B traits: a three-group family study of suicide controlling for major depressive disorder

A McGirr, M Alda, M Séguin, S Cabot… - American Journal of …, 2009 - Am Psychiatric Assoc
Objective: There is substantial evidence suggesting that suicide aggregates in families.
However, the extent of overlap between the liability to suicide and psychiatric disorders, …