Over the 75‐year lifetime of the British Pharmacological Society there has been an enormous
expansion in our understanding of how opioid drugs act on the nervous system, with much …

Following the elucidation of the amino acid sequences of the μ-, δ- and κ-opioid receptors, a
new ‘orphan opioid receptor' was cloned with a high degree of homology to the ‘classical' …

It is generally accepted that there are three subtypes of opiate receptor: µ, δ and κ. The main
endogenous ligands for the µ-and δ-sites are Met 5 -enkephalin, Leu 5 -enkephalin and β-…

The effect of gabapentin on the release of the spinal sensory neurotransmitter glutamate has
been investigated in an in vitro model using a perfused thin slice preparation from the rat …

Nociceptin, an endogenous ligand for the orphan receptor ORL 1 , has recently been described.
In this study we have shown that nociception inhibits 46 mM K + ‐stimulated glutamate …

Rationale: Psychological dependence to the opioid analgesic morphine is attributable to the
rewarding properties of the drug, and its evolution can be divided into two distinct phases: …

The effects of PD 176252 [3-(1H-indol-3-yl)-N-[1-(5-methoxy-pyridin-2-yl)-cyclohexylmethyl]-2-methyl-2-[3-(nitro-phenyl)ureido]propionamide],
a nonpeptide bombesin (BB) BB 1 /BB 2 …

The effect of activation of protein kinase C (PKC) or adenylyl cyclase on release of glutamate
has been investigated in a perfused slice preparation from the rat caudal trigeminal nucleus…

Various agents that have been reported to reduce the enzymatic degradation of the enkephalins
have been tested for their ability to potentiate the activity of [Met 5 ]enkephalin in three …

Nociceptin(NC) is the endogenous ligand for the opioid receptor like‐1 receptor (NC‐receptor).
[Phe 1 ΨC(CH 2 ‐NH)Gly 2 ]Nociceptin(1–13)NH 2 ([F/G]NC(1–13)NH 2 ) has been …