Importance Individuals can be classified as being at clinical high risk (CHR) for psychosis if
they meet at least one of the ultra–high-risk (UHR) inclusion criteria (brief limited intermittent …

In the last decade, there has been an increasing interest in cognitive alterations during the
early course of schizophrenia. From a clinical perspective, a better understanding of cognitive …

BACKGROUND: Most effort in ultra high-risk (UHR) research has been directed at defining
the clinical and neurobiological characteristics of those UHR subjects who go on to develop …

Recent evidence suggests that transition risks from initial clinical high risk (CHR) status to
psychosis are decreasing. The role played by remission in this context is mostly unknown. The …

OBJECTIVE: To investigate the proportion of patients among subjects initially identified as
fulfilling the ultra-high risk (UHR) criteria for psychosis using the Scale of Prodromal …

Importance Brain imaging studies have identified robust changes in brain structure and function
during the development of psychosis, but the contribution of abnormal brain connectivity …

The ability to detect individuals at high risk for developing schizophrenia before they express
the disease will lead to targeted early intervention. It has been proposed that subjects at …

Introduction Understanding the help-seeking pathways of patients with a putative risk of
developing psychosis helps improving development of specialised care services. This study …

BACKGROUND: Cognitive impairment is prevalent in at-risk mental states (ARMS) for
psychosis. METHOD: We studied cognitive functioning at baseline in ARMS individuals and …

Objectives: Neurofunctional alterations are correlates of vulnerability to psychosis, as well
as of the disorder itself. How these abnormalities relate to different probabilities for later …