The clinical use of deep brain stimulation (DBS) is among the most important advances in
the clinical neurosciences in the past two decades. As a surgical tool, DBS can directly …

Objective Alzheimer disease (AD) is characterized by functional impairment in the neural
elements and circuits underlying cognitive and memory functions. We hypothesized that fornix/…

Treatment-resistant depression is a severely disabling disorder with no proven treatment
options once multiple medications, psychotherapy, and electroconvulsive therapy have failed. …

Deep brain stimulation (DBS) is a neurosurgical procedure that allows targeted circuit-based
neuromodulation. DBS is a standard of care in Parkinson disease, essential tremor and …

Pathophysiology The establishment of a model of parkinsonism through the administration
of MPTP to nonhuman primates has provided important insights into new therapeutic …

Objective: To provide recommendations to patients, physicians, and other health care
providers on several issues involving deep brain stimulation (DBS) for Parkinson disease (PD). …

BACKGROUND: A preliminary report in six patients suggested that deep brain stimulation (DBS)
of the subcallosal cingulate gyrus (SCG) may provide benefit in treatment-resistant …

Akinesia and gait disturbances are particularly incapacitating for patients with Parkinson's
disease. The anatomical and physiological substrates for these disturbances are poorly …

Background Uncontrolled pilot studies have suggested the efficacy of focused ultrasound
thalamotomy with magnetic resonance imaging (MRI) guidance for the treatment of essential …

Although it is widely accepted that the cortex participates in pain perception, there is no direct
evidence for the existence of cortical neurons that respond to noxious or painful stimuli in …