A very fast empirical method is presented for structure‐based protein pK a prediction and
rationalization. The desolvation effects and intra‐protein interactions, which cause variations in …

The tendency of proteins to spontaneously adopt a well-defined conformation in solution
has intrigued investigators for many decades. 1 The key questions in the study of this …

Importance Psoriasis and psoriatic arthritis inflict significant morbidity. Data on undertreatment,
treatment use, and treatment satisfaction are paramount to identify priority areas for …

An analysis of the thermodynamics of protein stability reveals a general tendency for proteins
that denature at higher temperatures to have greater free energies of maximal stability. To …

Relationships between protein structure and ionization of carboxyl groups were investigated
in 24 proteins of known structure and for which 115 aspartate and 97 glutamate pK a values …

Ubiquitin (Ub) attachment to cell surface proteins causes their lysosomal degradation by
incorporating them into lumenal membranes of multivesicular bodies (MVBs). Two yeast …

Removal of the normal head-to-foot gravity vector and chronic weightlessness during
spaceflight might induce cardiovascular and metabolic adaptations related to changes in arterial …

Accurate lesion segmentation is critical in stroke rehabilitation research for the quantification
of lesion burden and accurate image processing. Current automated lesion segmentation …

Cerebral autoregulation (CA) refers to the control of cerebral tissue blood flow (CBF) in
response to changes in perfusion pressure. Due to the challenges of measuring intracranial …

Ubiquitination functions as a sorting signal for lysosomal degradation of cell-surface
proteins by facilitating their internalization from the plasma membrane and incorporation into …