Methods We searched PubMed, and Embase databases and classified the articles
depending on the epigenetic mechanisms (DNA methylation, histone modifications and non-coding …

Fragile X syndrome (FXS) is the most frequent inherited cause of intellectual disability and
the best-studied monogenic cause of autism. FXS results from the functional absence of the …

Fragile X syndrome (FXS) is the most frequent form of inherited intellectual disability and the
best-described monogenic cause of autism. CGG-repeat expansion in the FMR1 gene …

Background information Sumoylation is a key post‐translational modification by which the
Small Ubiquitin‐like MOdifier (SUMO) polypeptide is covalently attached to specific lysine …

The fragile X mental retardation protein (FMRP) is an RNA-binding protein involved in
translational regulation of mRNAs that play key roles in synaptic morphology and plasticity. The …

Background: Bipolar disorder is characterized by cyclical alternation between mania and
depression, often comorbid with psychosis and suicide. Compared with other medications, the …

Fine control of protein stoichiometry at synapses underlies brain function and plasticity. How
proteostasis is controlled independently for each type of synaptic protein in a synapse-…

Sumoylation plays important roles in the modulation of protein function, neurotransmission
and plasticity, but the mechanisms regulating this post-translational system in neurons remain …

The USP19 deubiquitinase is found in a locus associated with Parkinson’s Disease (PD),
interacts with chaperonins, and promotes secretion of α-synuclein (α-syn) through the …

Essential tremor (ET) is one of the most common movement disorders, affecting nearly 5%
of individuals over 65 years old. Despite this, few genetic risk loci for ET have been identified. …