Alterations in GABAergic mRNA expression play a key role for prefrontal dysfunction in
schizophrenia and other neurodevelopmental disease. Here, we show that histone H3-lysine 4 …

Little is known about the regulation of neuronal and other cell-type specific epigenomes
from the brain. Here, we map the genome-wide distribution of trimethylated histone H3K4 (…

Non-alcoholic fatty liver disease is prevalent in human obesity and type 2 diabetes, and is
characterized by increases in both hepatic triglyceride accumulation (denoted as steatosis) …

Background DNA-protein interactions in mature brain are increasingly recognized as key
regulators for behavioral plasticity and neuronal dysfunction in chronic neuropsychiatric …

Objective Adipose tissue (AT) inflammation is associated with systemic insulin resistance
and hyperinsulinemia in obese rodents and humans. A longstanding concept is that …

Neurons in the human brain become postmitotic largely during prenatal development, and
thus maintain their nuclei throughout the full lifespan. However, little is known about changes …

Chromatin remodeling, including histone modification, is involved in stimulant-induced gene
expression and addiction behavior. To further explore the role of dopamine D 1 receptor …

Signalling pathways that control endothelial cell (EC) permeability, leukocyte adhesion and
inflammation are pivotal for atherosclerosis initiation and progression. Here we demonstrate …

Methylation and other covalent modifications of nucleosome core histones are key regulators
of chromatin structure and function, including epigenetic control of gene expression. For …

Inflammation induced by wound healing or infection activates local vascular endothelial
cells to mediate leukocyte rolling, adhesion, and extravasation by up-regulation of leukocyte …