We examined whether consciously undetected fear signals engage a collateral brainstem
pathway to the amygdala and prefrontal cortex in the intact human brain, using functional …

OBJECTIVE: The authors investigated impaired differentiation of limbic-prefrontal systems
by autonomic arousal in schizophrenia. It was predicted that paranoid patients would be …

OBJECTIVE—To examine associations between measures of diabetes and risk of fracture
in a population-based sample of older Australians. RESEARCH DESIGN AND METHODS—…

The experience and appraisal of threat is essential to human and animal survival. Lesion
evidence suggests that the subjective experience of fear relies upon amygdala-medial frontal …

Effective fear processing relies on the amygdala and medial prefrontal cortex (MPFC). Post-trauma
reactions provide a compelling model for examining how the heightened experience …

Patterns of gray matter (GM) loss were measured in 223 healthy subjects spanning eight
decades. We observed significant clusters of accelerated loss in focal regions of the frontal and …

Contrary to the pervasive negative stereotypes of human aging, emotional functions may
improve with advancing age. However, the brain mechanisms underlying changes in emotional …

Facial expressions of fear are universally recognized signals of potential threat. Humans
may have evolved specialized neural systems for responding to fear in the absence of …

METHOD Eight individuals (5 females) with PTSD following assault (n= 4) or car accidents (n=
4) were recruited from the Westmead PTSD Unit, New South Wales, Australia. Average …

Biological models of posttraumatic stress disorder (PTSD) suggest that patients will display
heightened amygdala but decreased medial prefrontal activity during processing of fear …